The BF3.OEt2 mediated intramolecular cyclization of the γ-oxo-substituted allylic tin (1) having an aldehyde group at the terminus of the carbon chain proceeded in a stereocontrolled manner to give the 7-membered β-hydroxy cyclic ether (2a) with high diastereoselectivity. This method was applied for the synthesis of the 6·7·7·6 ring system (3a).
|Number of pages||4|
|Publication status||Published - Nov 25 1991|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry