Stereoselective synthesis and absolute configuration of the C1′-C25′ fragment of symbiodinolide

Hiroyoshi Takamura; Takeshi Murata; Takahiro Asai; Isao Kadota; Daisuke Uemura

doi:10.1021/jo901162v

Stereoselective synthesis and absolute configuration of the C1′-C25′ fragment of symbiodinolide

Hiroyoshi Takamura, Takeshi Murata, Takahiro Asai, Isao Kadota, Daisuke Uemura

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

(Chemical Equation Presented) Stereoselective synthesis of the C1′-C25′ fragment of symbiodinolide, which was obtained as a degraded product from symbiodinolide by alkaline hydrolysis, has been accomplished. The synthetic route features Kotsuki coupling and Julia-Kocienski olefination in the introduction of the side chains. This enantioand stereoselective synthesis has established the absolute configuration of the C1′-C25′ fragment.

Original language	English
Pages (from-to)	6658-6666
Number of pages	9
Journal	Journal of Organic Chemistry
Volume	74
Issue number	17
DOIs	https://doi.org/10.1021/jo901162v
Publication status	Published - Sept 4 2009

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo901162v

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AU - Asai, Takahiro

AU - Kadota, Isao

AU - Uemura, Daisuke

PY - 2009/9/4

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Stereoselective synthesis and absolute configuration of the C1′-C25′ fragment of symbiodinolide

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