Stereoselective synthesis of (E)-ArCFCFR and (E)-ArCHCFR from ArCH(OH)CFBr2

Manabu Kuroboshi, Nobuko Yamada, Yoko Takebe, Tamejiro Hiyama

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


(E)-vic-Difluoro olefin, RCFCFBr, was synthesized by dehydrobromination of RCFHCFBr2 using lithium 2,2,6,6-tetramethylpiperidide. (E)-Fluoro olefin, RCHCFBr, was obtained by treatment of RCH(OAc)CFBr2 with EtMgBr and HN(i-Pr)2.

Original languageEnglish
Pages (from-to)6271-6274
Number of pages4
JournalTetrahedron Letters
Issue number35
Publication statusPublished - Aug 28 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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