Stereospecific reduction of phosphine oxides to phosphines by the use of a methylation reagent and lithium aluminum hydride

Tsuneo Imamoto; Shin Ichi Kikuchi; Tomoya Miura; Yoshiyuki Wada

doi:10.1021/ol0068041

Stereospecific reduction of phosphine oxides to phosphines by the use of a methylation reagent and lithium aluminum hydride

Tsuneo Imamoto, Shin Ichi Kikuchi, Tomoya Miura, Yoshiyuki Wada

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

(equation presented) Various phosphine oxides are efficiently reduced by the use of a methylation reagent and lithium aluminum hydride. Optically active P-chirogenic phosphine oxides are also reduced with inversion of configuration at phosphorus atom by treatment with methyl triflate, followed by reaction with LiAlH₄.

Original language	English
Pages (from-to)	87-90
Number of pages	4
Journal	Organic Letters
Volume	3
Issue number	1
DOIs	https://doi.org/10.1021/ol0068041
Publication status	Published - Jan 11 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0068041

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@article{4308055ac5ed402ca4ff2f1e1d9db0ab,

title = "Stereospecific reduction of phosphine oxides to phosphines by the use of a methylation reagent and lithium aluminum hydride",

abstract = "(equation presented) Various phosphine oxides are efficiently reduced by the use of a methylation reagent and lithium aluminum hydride. Optically active P-chirogenic phosphine oxides are also reduced with inversion of configuration at phosphorus atom by treatment with methyl triflate, followed by reaction with LiAlH4.",

author = "Tsuneo Imamoto and Kikuchi, {Shin Ichi} and Tomoya Miura and Yoshiyuki Wada",

year = "2001",

month = jan,

day = "11",

doi = "10.1021/ol0068041",

language = "English",

volume = "3",

pages = "87--90",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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T1 - Stereospecific reduction of phosphine oxides to phosphines by the use of a methylation reagent and lithium aluminum hydride

AU - Imamoto, Tsuneo

AU - Kikuchi, Shin Ichi

AU - Miura, Tomoya

AU - Wada, Yoshiyuki

PY - 2001/1/11

Y1 - 2001/1/11

N2 - (equation presented) Various phosphine oxides are efficiently reduced by the use of a methylation reagent and lithium aluminum hydride. Optically active P-chirogenic phosphine oxides are also reduced with inversion of configuration at phosphorus atom by treatment with methyl triflate, followed by reaction with LiAlH4.

AB - (equation presented) Various phosphine oxides are efficiently reduced by the use of a methylation reagent and lithium aluminum hydride. Optically active P-chirogenic phosphine oxides are also reduced with inversion of configuration at phosphorus atom by treatment with methyl triflate, followed by reaction with LiAlH4.

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DO - 10.1021/ol0068041

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C2 - 11429879

AN - SCOPUS:0002926693

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VL - 3

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JO - Organic Letters

JF - Organic Letters

IS - 1

ER -

Stereospecific reduction of phosphine oxides to phosphines by the use of a methylation reagent and lithium aluminum hydride

Abstract

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