Structural diversity of murine serum amyloid A genes: Evolutionary implications

K. I. Yamamoto, N. Goto, J. Kosaka, M. Shiroo, Y. D. Yeul, S. Migita

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Mouse serum amyloid A (SAA) gene family comprises four members that are closely linked in the chromosome 7. Two of these genes encoding major mouse SAA isotypes (SAA1 and SAA2) are highly homologous not only in exons but also in introns and flanking regions; this sequence homology extends 280 base pairs upstream of major cap sites and 430 base pairs downstream of polyadenylation sites, and the 5' boundary of this homology unit is marked by the CA/GT repeat. Sequence comparison also shows that one (SAA4) of the other two genes is related to the SAA1/2 gene, whereas the other gene (SAA3) evolved independently. Based on these results and the SAA gene arrangement, we discussed mouse SAA gene evolution.

Original languageEnglish
Pages (from-to)1683-1688
Number of pages6
JournalJournal of Immunology
Issue number5
Publication statusPublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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