TY - JOUR
T1 - Structural diversity of murine serum amyloid A genes
T2 - Evolutionary implications
AU - Yamamoto, K. I.
AU - Goto, N.
AU - Kosaka, J.
AU - Shiroo, M.
AU - Yeul, Y. D.
AU - Migita, S.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - Mouse serum amyloid A (SAA) gene family comprises four members that are closely linked in the chromosome 7. Two of these genes encoding major mouse SAA isotypes (SAA1 and SAA2) are highly homologous not only in exons but also in introns and flanking regions; this sequence homology extends 280 base pairs upstream of major cap sites and 430 base pairs downstream of polyadenylation sites, and the 5' boundary of this homology unit is marked by the CA/GT repeat. Sequence comparison also shows that one (SAA4) of the other two genes is related to the SAA1/2 gene, whereas the other gene (SAA3) evolved independently. Based on these results and the SAA gene arrangement, we discussed mouse SAA gene evolution.
AB - Mouse serum amyloid A (SAA) gene family comprises four members that are closely linked in the chromosome 7. Two of these genes encoding major mouse SAA isotypes (SAA1 and SAA2) are highly homologous not only in exons but also in introns and flanking regions; this sequence homology extends 280 base pairs upstream of major cap sites and 430 base pairs downstream of polyadenylation sites, and the 5' boundary of this homology unit is marked by the CA/GT repeat. Sequence comparison also shows that one (SAA4) of the other two genes is related to the SAA1/2 gene, whereas the other gene (SAA3) evolved independently. Based on these results and the SAA gene arrangement, we discussed mouse SAA gene evolution.
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M3 - Article
C2 - 3624868
AN - SCOPUS:0023199831
SN - 0022-1767
VL - 139
SP - 1683
EP - 1688
JO - Journal of Immunology
JF - Journal of Immunology
IS - 5
ER -