Structure and in vitro solubility of silicon-substituted hydroxyapatite

Tomoko Kanaya, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Eiji Fujii, Koji Kawabata, Georgiana Gasqueresc, Christian Bonhomme, Florence Babonneau

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Hydroxyapatite (HAp) and Si-containing hydroxyapatite (SiHAp) particles were synthesized by a wet chemical method. Local structures around Si, P and H in the hydroxyapatites were analyzed by solid-state magic-angle spinning nuclear magnetic resonance spectroscopy. In vitro solubility of those SiHAp particles was evaluated by soaking them in acetic acid/acetate buffer solution (pH=4.0) at 36.5°C. As the Si content increased, the in vitro solubility of the SiHAp particles increased, while their crystallite size changed little.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalKey Engineering Materials
Volume361-363 I
Publication statusPublished - 2008


  • Hydroxyapatite
  • In vitro solubility
  • Silicon
  • Structure analysis

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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