TY - JOUR
T1 - Structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, at 2.4 Å resolution
T2 - A putative member of the StAR-related lipid-transfer (START) domain superfamily
AU - Nakabayashi, Makoto
AU - Shibata, Naoki
AU - Komori, Hirofumi
AU - Ueda, Yasufumi
AU - Iino, Hitoshi
AU - Ebihara, Akio
AU - Kuramitsu, Seiki
AU - Higuchi, Yoshiki
PY - 2005
Y1 - 2005
N2 - The crystal structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, has been determined at 2.4 Å resolution as a part of a structural and functional genomics project on T. thermophilus HB8. The main-chain folding shows a compact α+β motif, forming a hydrophobic cavity in the molecule. A structural similarity search reveals that it resembles those steroidogenic acute regulatory proteins that contain the lipid-transfer (START) domain, even though TTHA0849 shows comparatively weak sequence identity to polyketide cyclases. However, the size of the ligand-binding cavity is distinctly smaller than other START domain-containing proteins, suggesting that it catalyses the transfer of smaller ligand molecules.
AB - The crystal structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, has been determined at 2.4 Å resolution as a part of a structural and functional genomics project on T. thermophilus HB8. The main-chain folding shows a compact α+β motif, forming a hydrophobic cavity in the molecule. A structural similarity search reveals that it resembles those steroidogenic acute regulatory proteins that contain the lipid-transfer (START) domain, even though TTHA0849 shows comparatively weak sequence identity to polyketide cyclases. However, the size of the ligand-binding cavity is distinctly smaller than other START domain-containing proteins, suggesting that it catalyses the transfer of smaller ligand molecules.
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U2 - 10.1107/S1744309105035372
DO - 10.1107/S1744309105035372
M3 - Article
C2 - 16511226
AN - SCOPUS:33744480790
SN - 1744-3091
VL - 61
SP - 1027
EP - 1031
JO - Acta Crystallographica Section F: Structural Biology and Crystallization Communications
JF - Acta Crystallographica Section F: Structural Biology and Crystallization Communications
IS - 12
ER -