Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant enterococcus species

Eerdunbayaer; Mohamed A.A. Orabi; Hiroe Aoyama; Teruo Kuroda; Tsutomu Hatano

doi:10.3390/molecules19043883

Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant enterococcus species

Eerdunbayaer, Mohamed A.A. Orabi, Hiroe Aoyama, Teruo Kuroda, Tsutomu Hatano

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.

Original language	English
Pages (from-to)	3883-3897
Number of pages	15
Journal	Molecules
Volume	19
Issue number	4
DOIs	https://doi.org/10.3390/molecules19043883
Publication status	Published - Apr 2014
Externally published	Yes

Keywords

2-arylcoumarone
3-arylcoumarin
Antibacterial effect
Flavonoid
Glycyrrhiza uralensis
Licorice
Phenolics
VRE

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules19043883

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title = "Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant enterococcus species",

abstract = "Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.",

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AU - Aoyama, Hiroe

AU - Kuroda, Teruo

AU - Hatano, Tsutomu

PY - 2014/4

Y1 - 2014/4

N2 - Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.

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KW - 3-arylcoumarin

KW - Antibacterial effect

KW - Flavonoid

KW - Glycyrrhiza uralensis

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KW - Phenolics

KW - VRE

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ER -

Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant enterococcus species

Abstract

Keywords

ASJC Scopus subject areas

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