Studies of Superoxide Dismutase in Rat Gastric Mucosal Damage (The 2nd Report) —Pathogenesis of Indomethacin Induced Gastric Ulcer—

Keiki Ogino; Shinji Oka; Shinjiro Mazuura; Isao Sakaida; Shunji Yoshimura; Kazuya Mazuda; Toshiyuki Sasaki; Kazunari Yamamoto; Tadayoshi Takemoto; Yukinori Okazaki

doi:10.11405/nisshoshi1964.84.1389

Studies of Superoxide Dismutase in Rat Gastric Mucosal Damage (The 2nd Report) —Pathogenesis of Indomethacin Induced Gastric Ulcer—

Keiki Ogino, Shinji Oka, Shinjiro Mazuura, Isao Sakaida, Shunji Yoshimura, Kazuya Mazuda, Toshiyuki Sasaki, Kazunari Yamamoto, Tadayoshi Takemoto, Yukinori Okazaki

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesion. In this report, it was clarified that superoxide dismutase (SOD) and catalase had inhibitory effect on indomethacin-induced gastric ulcer. SOD had the effect of increasing tendency in gastric mucosal blood flow, inhibitory action on gastric acid secretion and promotive tendency of prostaglandin E₂ synthesis in normal adult rats. Therefore, it was suggested that inhibitory effect of SOD and catalase on indomethacin-induced gastric ulcer may be due to decrease of inhibition of prostaglandin E₂ synthesis or due to the pathogenesis of indomethacin-induced gastric ulcer in association with endotoxin.

Original language	English
Pages (from-to)	1389-1393
Number of pages	5
Journal	Nippon Shokakibyo Gakkai Zasshi
Volume	84
Issue number	7
DOIs	https://doi.org/10.11405/nisshoshi1964.84.1389
Publication status	Published - Jan 1 1987

ASJC Scopus subject areas

Gastroenterology

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Ogino, K, Oka, S, Mazuura, S, Sakaida, I, Yoshimura, S, Mazuda, K, Sasaki, T, Yamamoto, K, Takemoto, T & Okazaki, Y 1987, 'Studies of Superoxide Dismutase in Rat Gastric Mucosal Damage (The 2nd Report) —Pathogenesis of Indomethacin Induced Gastric Ulcer—', Nippon Shokakibyo Gakkai Zasshi, vol. 84, no. 7, pp. 1389-1393. https://doi.org/10.11405/nisshoshi1964.84.1389

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abstract = "It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesion. In this report, it was clarified that superoxide dismutase (SOD) and catalase had inhibitory effect on indomethacin-induced gastric ulcer. SOD had the effect of increasing tendency in gastric mucosal blood flow, inhibitory action on gastric acid secretion and promotive tendency of prostaglandin E2 synthesis in normal adult rats. Therefore, it was suggested that inhibitory effect of SOD and catalase on indomethacin-induced gastric ulcer may be due to decrease of inhibition of prostaglandin E2 synthesis or due to the pathogenesis of indomethacin-induced gastric ulcer in association with endotoxin.",

author = "Keiki Ogino and Shinji Oka and Shinjiro Mazuura and Isao Sakaida and Shunji Yoshimura and Kazuya Mazuda and Toshiyuki Sasaki and Kazunari Yamamoto and Tadayoshi Takemoto and Yukinori Okazaki",

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AU - Mazuura, Shinjiro

AU - Sakaida, Isao

AU - Yoshimura, Shunji

AU - Mazuda, Kazuya

AU - Sasaki, Toshiyuki

AU - Yamamoto, Kazunari

AU - Takemoto, Tadayoshi

AU - Okazaki, Yukinori

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AB - It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesion. In this report, it was clarified that superoxide dismutase (SOD) and catalase had inhibitory effect on indomethacin-induced gastric ulcer. SOD had the effect of increasing tendency in gastric mucosal blood flow, inhibitory action on gastric acid secretion and promotive tendency of prostaglandin E2 synthesis in normal adult rats. Therefore, it was suggested that inhibitory effect of SOD and catalase on indomethacin-induced gastric ulcer may be due to decrease of inhibition of prostaglandin E2 synthesis or due to the pathogenesis of indomethacin-induced gastric ulcer in association with endotoxin.

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Studies of Superoxide Dismutase in Rat Gastric Mucosal Damage (The 2nd Report) —Pathogenesis of Indomethacin Induced Gastric Ulcer—

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