TY - JOUR
T1 - Studies of the mechanism of action of the aerolysin-like hemolysin of Aeromonas sobria in stimulating T84 cells to produce cyclic AMP
AU - Fujii, Yoshio
AU - Nomura, Tomohiko
AU - Yokoyama, Ritsuko
AU - Shinoda, Sumio
AU - Okamoto, Keinosuke
PY - 2003/3/1
Y1 - 2003/3/1
N2 - We previously reported that the aerolysin-like hemolysin of Aeromonas sobria stimulates T84 cells to produce cyclic AMP, which then emerges in the culture medium. In order to clarify the mechanism of action of the hemolysin, we examined the involvement of adenosine nucleotide. The results show that the hemolysin stimulates T84 cells to release ATP, which is then converted to adenosine by ectonucleotidase. The adenosine generated might stimulate the P1 adenosine receptors of T84 cells to produce cyclic AMP.
AB - We previously reported that the aerolysin-like hemolysin of Aeromonas sobria stimulates T84 cells to produce cyclic AMP, which then emerges in the culture medium. In order to clarify the mechanism of action of the hemolysin, we examined the involvement of adenosine nucleotide. The results show that the hemolysin stimulates T84 cells to release ATP, which is then converted to adenosine by ectonucleotidase. The adenosine generated might stimulate the P1 adenosine receptors of T84 cells to produce cyclic AMP.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037373129&partnerID=8YFLogxK
U2 - 10.1128/IAI.71.3.1557-1560.2003
DO - 10.1128/IAI.71.3.1557-1560.2003
M3 - Article
C2 - 12595476
AN - SCOPUS:0037373129
SN - 0019-9567
VL - 71
SP - 1557
EP - 1560
JO - Infection and Immunity
JF - Infection and Immunity
IS - 3
ER -
