Studies on Hemolytic Action of a Hemolysin Produced by Vibrio mimicus

Sumin Shinnda, Kazuhiko Ishida, Eun Gyoung Oh, Kazuhiro Sasahara, Shin ichi Miyoshi, Mohammad Afzalur Rahim Chowdhurv, Tatsuji Yasuda

Research output: Contribution to journalArticlepeer-review


Some properties and mechanism of action of a hemolysin (VMH) produced by an enteropathogenic Vibrio mimicus strain was examined. VMH was heat-labile and inhibited by addition of divalent cations, including Ca2+, Mg2+ and Mn2+. The hemolysis by VMH was inhibited by incubating with gangliosides, suggesting that the ganglioside was the binding site on the erythrocyte membrane for VMH. Existence of a galactose moiety on reducing end of the ganglioside molecule and a sialic acid on the galactose moiety was suggested to be important for the binding of VMH molecule. Colloid osmotic manner of the hemolysis by VMH was demonstrated.

Original languageEnglish
Pages (from-to)774-777
Number of pages4
Issue number5
Publication statusPublished - Jan 1 1993


  • Gangliosides
  • Hemolysin
  • Vibrio mimicus

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology


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