TY - JOUR
T1 - Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation
AU - Kataoka, Takahiro
AU - Sakoda, Akihiro
AU - Yoshimoto, Masaaki
AU - Nakagawa, Shinya
AU - Toyota, Teruaki
AU - Nishiyama, Yuichi
AU - Yamato, Keiko
AU - Ishimori, Yuu
AU - Kawabe, Atsushi
AU - Hanamoto, Katsumi
AU - Taguchi, Takehito
AU - Yamaoka, Kiyonori
PY - 2011/7
Y1 - 2011/7
N2 - Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl4) administration. Results showed that radon inhalation alleviates CCl4-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.
AB - Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl4) administration. Results showed that radon inhalation alleviates CCl4-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.
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UR - http://www.scopus.com/inward/citedby.url?scp=79960181625&partnerID=8YFLogxK
U2 - 10.1093/rpd/ncr189
DO - 10.1093/rpd/ncr189
M3 - Article
C2 - 21543347
AN - SCOPUS:79960181625
SN - 0144-8420
VL - 146
SP - 360
EP - 363
JO - Radiation Protection Dosimetry
JF - Radiation Protection Dosimetry
IS - 1-3
M1 - ncr189
ER -
