Studies on the sleep-inducing effect of diphenhydramine hydrochloride

Chiaki Kamei; Koichi Saito; Yukio Sugimoto; Zhong Chen; Qiue Zhao

Studies on the sleep-inducing effect of diphenhydramine hydrochloride

Chiaki Kamei, Koichi Saito, Yukio Sugimoto, Zhong Chen, Qiue Zhao

Research output: Contribution to journal › Article › peer-review

Abstract

The present study was undertaken to clarify whether or not diphenhydramine is useful for sedative-hypnotic drug. EEG power spectra of delta band (0-4 Hz) at the frontal cortex in rats was used for an index of sleep. Diphenhydramine at doses of 2-20mg/kg, p.o. caused a dose-dependent shortening of sleep latency and prolongation of sleep duration. Significant effect was observed at a dose of 10mg/kg or more. These effects were almost the same as those of chlorpheniramine and less than those of brotizolam. The results clearly indicate that diphenhydramine is effective sedative-hypnotic drug for mild insomnia.

Original language	English
Pages (from-to)	18-19
Number of pages	2
Journal	Japanese Pharmacology and Therapeutics
Volume	27
Issue number	5
Publication status	Published - Dec 1 1999

Keywords

Diphenhydramine
EEG power spectra
Sleep

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

Cite this

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AU - Kamei, Chiaki

AU - Saito, Koichi

AU - Sugimoto, Yukio

AU - Chen, Zhong

AU - Zhao, Qiue

PY - 1999/12/1

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N2 - The present study was undertaken to clarify whether or not diphenhydramine is useful for sedative-hypnotic drug. EEG power spectra of delta band (0-4 Hz) at the frontal cortex in rats was used for an index of sleep. Diphenhydramine at doses of 2-20mg/kg, p.o. caused a dose-dependent shortening of sleep latency and prolongation of sleep duration. Significant effect was observed at a dose of 10mg/kg or more. These effects were almost the same as those of chlorpheniramine and less than those of brotizolam. The results clearly indicate that diphenhydramine is effective sedative-hypnotic drug for mild insomnia.

AB - The present study was undertaken to clarify whether or not diphenhydramine is useful for sedative-hypnotic drug. EEG power spectra of delta band (0-4 Hz) at the frontal cortex in rats was used for an index of sleep. Diphenhydramine at doses of 2-20mg/kg, p.o. caused a dose-dependent shortening of sleep latency and prolongation of sleep duration. Significant effect was observed at a dose of 10mg/kg or more. These effects were almost the same as those of chlorpheniramine and less than those of brotizolam. The results clearly indicate that diphenhydramine is effective sedative-hypnotic drug for mild insomnia.

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Studies on the sleep-inducing effect of diphenhydramine hydrochloride

Abstract

Keywords

ASJC Scopus subject areas

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