Study on enzymatic hydrolysis of polylactic acid by endogenous depolymerizaion model

Masaji Watanabe, Fusako Kawai, Sadao Tsuboi, Shogo Nakatsu, Hitomi Ohara

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Enzymatic degradation of polylactic acid is studied experimentally and analytically. Gel permeation chromatography profiles obtained before and after the enzymatic degradation of polylactic acid (PLA) were introduced into the analysis based on a mathematical model. Previously developed techniques were successfully adapted to the analysis of an initial value problem consisting of an endogenous depolymerization model and an initial condition, and an inverse problem to determine the degradation rate for which the solution of the initial value problem also satisfies a final condition. Those problems were solved numerically and numerical results are introduced. Degradabilities of PLA and polyvinyl alcohol are compared.

Original languageEnglish
Pages (from-to)619-626
Number of pages8
JournalMacromolecular Theory and Simulations
Issue number6
Publication statusPublished - Aug 27 2007


  • Degradation
  • Differential equation
  • Distribution
  • Enzymatic degradation
  • Inverse problem
  • Mathematical model
  • Numerical simulation
  • Polylactic acid

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry


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