Study on site specific cleavage of RNA.

H. Shirakura, K. Hosono, G. Kawai, K. Takai, T. Ohtsuki, K. Watanabe, K. Sakamoto, S. Yokoyama, H. Takaku

Research output: Contribution to journalArticlepeer-review


The precursor of an RNA molecule from bacteriophage T4 infected Escherichia coli cell (p2Sp1 RNA) has the ability to cleave itself. It has been found that the site specific RNA cleavage reaction occurred at the pyridine-adenosine sequence in the presence of a monovalent cation and a non-ionic detergent. In order to investigate the mechanism of this cleavage reaction, we designed a RNA oligonucleotide (UUUAUU) and this RNA was cleavage activity at the U-A sequence.

Original languageEnglish
Pages (from-to)217-218
Number of pages2
JournalNucleic acids symposium series
Issue number37
Publication statusPublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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