Stylissamide I, a new cyclic heptapeptide from an okinawan marine sponge Stylissa sp.

Takaaki Kubota; Kenta Nakamura; Shin Ichiro Kurimoto; Kanae Sakai; Jane Fromont; Tohru Gonoi; Jun'ichi Kobayashi

doi:10.3987/COM-16-S(S)45

Stylissamide I, a new cyclic heptapeptide from an okinawan marine sponge Stylissa sp.

Takaaki Kubota, Kenta Nakamura, Shin Ichiro Kurimoto, Kanae Sakai, Jane Fromont, Tohru Gonoi, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

Abstract

A new cyclic heptapeptide, stylissamide I (1), was isolated from an Okinawan marine sponge Stylissa sp. The structure of stylissamide I (1) was elucidated to be cyclo-(L-Tyr1-L-Tyr2-L-Tyr3-L-Pro1-L-Pro2-L-Val-L-Pro3) by extensive spectral analyses and Marfey's method. Stylissamide I (1) showed antifungal activity against Aspergillus Niger.

Original language	English
Pages (from-to)	799-806
Number of pages	8
Journal	Heterocycles
Volume	95
Issue number	2
DOIs	https://doi.org/10.3987/COM-16-S(S)45
Publication status	Published - 2017
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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10.3987/COM-16-S(S)45

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title = "Stylissamide I, a new cyclic heptapeptide from an okinawan marine sponge Stylissa sp.",

abstract = "A new cyclic heptapeptide, stylissamide I (1), was isolated from an Okinawan marine sponge Stylissa sp. The structure of stylissamide I (1) was elucidated to be cyclo-(L-Tyr1-L-Tyr2-L-Tyr3-L-Pro1-L-Pro2-L-Val-L-Pro3) by extensive spectral analyses and Marfey's method. Stylissamide I (1) showed antifungal activity against Aspergillus Niger.",

author = "Takaaki Kubota and Kenta Nakamura and Kurimoto, {Shin Ichiro} and Kanae Sakai and Jane Fromont and Tohru Gonoi and Jun'ichi Kobayashi",

note = "Publisher Copyright: {\textcopyright} 2017 The Japan Institute of Heterocyclic Chemistry.",

year = "2017",

doi = "10.3987/COM-16-S(S)45",

language = "English",

volume = "95",

pages = "799--806",

journal = "Heterocycles",

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T1 - Stylissamide I, a new cyclic heptapeptide from an okinawan marine sponge Stylissa sp.

AU - Kubota, Takaaki

AU - Nakamura, Kenta

AU - Kurimoto, Shin Ichiro

AU - Sakai, Kanae

AU - Fromont, Jane

AU - Gonoi, Tohru

AU - Kobayashi, Jun'ichi

PY - 2017

Y1 - 2017

N2 - A new cyclic heptapeptide, stylissamide I (1), was isolated from an Okinawan marine sponge Stylissa sp. The structure of stylissamide I (1) was elucidated to be cyclo-(L-Tyr1-L-Tyr2-L-Tyr3-L-Pro1-L-Pro2-L-Val-L-Pro3) by extensive spectral analyses and Marfey's method. Stylissamide I (1) showed antifungal activity against Aspergillus Niger.

AB - A new cyclic heptapeptide, stylissamide I (1), was isolated from an Okinawan marine sponge Stylissa sp. The structure of stylissamide I (1) was elucidated to be cyclo-(L-Tyr1-L-Tyr2-L-Tyr3-L-Pro1-L-Pro2-L-Val-L-Pro3) by extensive spectral analyses and Marfey's method. Stylissamide I (1) showed antifungal activity against Aspergillus Niger.

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SN - 0385-5414

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EP - 806

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

Stylissamide I, a new cyclic heptapeptide from an okinawan marine sponge Stylissa sp.

Abstract

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UN SDGs

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