Subclinical atherosclerosis in primary antiphospholipid syndrome

Annamaria Margarita; Joana Batuca; Giovanna Scenna; Jose Delgado Alves; Louis Lopez; Luigi Iannaccone; Eiji Matsuura; Paul R.J. Ames

doi:10.1196/annals.1422.050

Subclinical atherosclerosis in primary antiphospholipid syndrome

Annamaria Margarita, Joana Batuca, Giovanna Scenna, Jose Delgado Alves, Louis Lopez, Luigi Iannaccone, Eiji Matsuura, Paul R.J. Ames

Neutron Therapy Research Center

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

33 Citations (Scopus)

Abstract

To test the atherosclerosis hypothesis in primary antiphospholipid syndrome (PAPS) we measured intima media thickness (IMT) of carotid arteries and other cardiovascular risk factors in 44 patients with PAPS (mean age 35 ± 12 years), in 25 patients with inherited thrombophilia (mean age 40 ± 10 years), and in 34 normal controls (mean age 38 ± 11 years). The frequency of smoking, hypertension, and dyslipidemia was similar across groups. IMT was almost similar across groups at age groups below 40 years but IMT was greater in PAPS than controls at the common carotid (P = 0.01), at the bifurcation (P = 0.003), and at the internal carotid (P = 0.005) in the age group over 40 years. Atherosclerosis is a possibility in PAPS patients in their fourth decade of life or older.

Original language	English
Title of host publication	Autoimmunity, Part D
Subtitle of host publication	Autoimmune Disease, Annus Mirabilis
Publisher	Blackwell Publishing Inc.
Pages	475-480
Number of pages	6
ISBN (Print)	157331708X, 9781573317085
DOIs	https://doi.org/10.1196/annals.1422.050
Publication status	Published - Jun 2007

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1108
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Atherosclerosis
Primary antiphospholipid syndrome

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1196/annals.1422.050

Cite this

Margarita, A., Batuca, J., Scenna, G., Alves, J. D., Lopez, L., Iannaccone, L., Matsuura, E., & Ames, P. R. J. (2007). Subclinical atherosclerosis in primary antiphospholipid syndrome. In Autoimmunity, Part D: Autoimmune Disease, Annus Mirabilis (pp. 475-480). (Annals of the New York Academy of Sciences; Vol. 1108). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1422.050

Subclinical atherosclerosis in primary antiphospholipid syndrome. / Margarita, Annamaria; Batuca, Joana; Scenna, Giovanna et al.
Autoimmunity, Part D: Autoimmune Disease, Annus Mirabilis. Blackwell Publishing Inc., 2007. p. 475-480 (Annals of the New York Academy of Sciences; Vol. 1108).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Subclinical atherosclerosis in primary antiphospholipid syndrome

Abstract

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Keywords

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