Subconvulsive dose of strychnine enhances the transneuronal effect of peripheral sensory nerve transection

Tomosada Sugimoto; Motohide Takemura; Johji Okubo; Akira Sakai

doi:10.1016/0006-8993(84)90306-8

Subconvulsive dose of strychnine enhances the transneuronal effect of peripheral sensory nerve transection

Tomosada Sugimoto, Motohide Takemura, Johji Okubo, Akira Sakai

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The effect of transection of the inferior alveolar nerve on the trigeminal subnucleus caudalis neuron was examined under the influence of systemic strychnine in the rat. Chronic intoxication with a subconvulsive dose of strychnine induced electron dense degeneration of somata and dendrites at 30 days following transection in the area of subnucleus caudalis which received primary projection from the transected nerve. Removal of the postsynaptic inhibition appears to enhance the transneuronal effect of peripheral nerve injury.

Original language	English
Pages (from-to)	320-325
Number of pages	6
Journal	Brain Research
Volume	323
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)90306-8
Publication status	Published - Dec 10 1984

Keywords

peripheral nerve injury
subnucleus caudalis
transneuronal degeneration
trigeminal nerve

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)90306-8

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abstract = "The effect of transection of the inferior alveolar nerve on the trigeminal subnucleus caudalis neuron was examined under the influence of systemic strychnine in the rat. Chronic intoxication with a subconvulsive dose of strychnine induced electron dense degeneration of somata and dendrites at 30 days following transection in the area of subnucleus caudalis which received primary projection from the transected nerve. Removal of the postsynaptic inhibition appears to enhance the transneuronal effect of peripheral nerve injury.",

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AU - Sugimoto, Tomosada

AU - Takemura, Motohide

AU - Okubo, Johji

AU - Sakai, Akira

PY - 1984/12/10

Y1 - 1984/12/10

N2 - The effect of transection of the inferior alveolar nerve on the trigeminal subnucleus caudalis neuron was examined under the influence of systemic strychnine in the rat. Chronic intoxication with a subconvulsive dose of strychnine induced electron dense degeneration of somata and dendrites at 30 days following transection in the area of subnucleus caudalis which received primary projection from the transected nerve. Removal of the postsynaptic inhibition appears to enhance the transneuronal effect of peripheral nerve injury.

AB - The effect of transection of the inferior alveolar nerve on the trigeminal subnucleus caudalis neuron was examined under the influence of systemic strychnine in the rat. Chronic intoxication with a subconvulsive dose of strychnine induced electron dense degeneration of somata and dendrites at 30 days following transection in the area of subnucleus caudalis which received primary projection from the transected nerve. Removal of the postsynaptic inhibition appears to enhance the transneuronal effect of peripheral nerve injury.

KW - peripheral nerve injury

KW - subnucleus caudalis

KW - transneuronal degeneration

KW - trigeminal nerve

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Subconvulsive dose of strychnine enhances the transneuronal effect of peripheral sensory nerve transection

Abstract

Keywords

ASJC Scopus subject areas

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