Subjective depressive mood and regional cerebral blood flow in mild Alzheimer's disease

Hajime Honda, Seishi Terada, Shuhei Sato, Etsuko Oshima, Chikako Ikeda, Shigeto Nagao, Osamu Yokota, Yosuke Uchitomi

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background: Depressive symptoms are common in patients with Alzheimer's disease (AD) and increase the caregiver burden, although the etiology and pathologic mechanism of depressive symptoms in AD patients remain unclear. In this study, we tried to clarify the cerebral blood flow (CBF) correlates of subjective depressive symptoms in AD. Methods: Seventy-six consecutive patients with AD were recruited from outpatient units of the Memory Clinic of Okayama University Hospital. Subjective depressive symptoms were evaluated using the short version of the Geriatric Depression Scale (GDS). All patients underwent brain SPECT with 99mTc-ethylcysteinate dimer, and the SPECT images were analyzed by the Statistical Parametric Mapping 8 program. Results: No significant differences between groups with high and low GDS scores were found with respect to age, sex, years of education, and revised Addenbrooke's Cognitive Examination scores. Compared to patients with low scores on GDS, patients with high scores showed significant hypoperfusion in the left inferior frontal region. Conclusions: The left inferior frontal region may be significantly involved in the pathogenesis of subjective depressive symptoms in AD. Subjective and objective depressive symptoms may have somewhat different neural substrates in AD.

Original languageEnglish
Pages (from-to)817-823
Number of pages7
JournalInternational Psychogeriatrics
Issue number5
Publication statusPublished - May 2014


  • Alzheimer's disease
  • Geriatric Depression Scale
  • depression
  • depressive symptom
  • regional cerebral blood flow

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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