Successful treatment of early myoclonic encephalopathy using lidocaine and carbamazepine

Kousuke Nakano, Katsuhiro Kobayashi, Satoshi Maniwa, Nobuyuki Kodani, Yoko Ohtsuka

Research output: Contribution to journalComment/debatepeer-review

6 Citations (Scopus)


We report two female infants with early myoclonic encephalopathy (EME) whose intractable focal seizures were suppressed with lidocaine and carbamazepine (CBZ). Although EME is a form of early-onset epileptic encephalopathy characterised by myoclonus and focal seizures that are highly resistant to treatment, lidocaine and CBZ may prove effective in treating this disorder. Future studies should be performed in order to determine whether there are common specific mechanisms of seizure generation related to the sodium channel in these patients.

Original languageEnglish
Pages (from-to)352-357
Number of pages6
JournalEpileptic Disorders
Issue number3
Publication statusPublished - Sept 1 2013


  • Carbamazepine
  • Early myoclonic encephalopathy
  • Focal seizures
  • Lidocaine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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