Successful treatment of epilepsy by resection of periventricular nodular heterotopia

Takashi Agari, Tadahiro Mihara, Koichi Baba, Katsuhiro Kobayashi, Naotaka Usui, Kiyohito Terada, Fumihiro Nakamura, Kazumi Matsuda, Isao Date

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


We report on a case of successful surgical treatment of drug-resistant epilepsy associated with a soli-tary lesion of periventricular nodular heterotopia (PNH). In the reported patient, intracranial ictal electroencephalography disclosed that seizures did not originate from the heterotopic nodules. However, the seizures were completely suppressed by lesionectomy of PNH alone. Epileptogenesis associated with PNH likely involves a very complex network between PNH and the surrounding cortex, and the disruption of this network may be an effective means of curing intractable, PNH-associated epilepsy.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalActa medica Okayama
Issue number6
Publication statusPublished - 2012


  • Epilepsy
  • Ictal electroencephalography
  • Periventricular nodular heterotopia
  • Surgery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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