Successful treatment of metastatic urothelial carcinoma after accurate diagnosis by immunohistochemistry

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Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalActa medica Okayama
Issue number3
Publication statusPublished - 2019


  • Carbohydrate antigen 19-9
  • Chemotherapy
  • S-pancreas-1 antigen
  • Uroplakin III
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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