Successful treatment of metastatic urothelial carcinoma after accurate diagnosis by immunohistochemistry

Go Makimoto; Hisakazu Nishimori; Reiko Kondo; Hiroyuki Yanai; Morito Sugimoto; Naohiro Oda; Toshio Kubo; Katsuyuki Hotta; Masahiro Tabata; Katsuyuki Kiura; Yoshinobu Maeda

Successful treatment of metastatic urothelial carcinoma after accurate diagnosis by immunohistochemistry

Go Makimoto, Hisakazu Nishimori, Reiko Kondo, Hiroyuki Yanai, Morito Sugimoto, Naohiro Oda, Toshio Kubo, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura, Yoshinobu Maeda

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.

Original language	English
Pages (from-to)	279-284
Number of pages	6
Journal	Acta medica Okayama
Volume	73
Issue number	3
Publication status	Published - 2019

Keywords

Carbohydrate antigen 19-9
Chemotherapy
S-pancreas-1 antigen
Uroplakin III
Urothelial carcinoma

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Successful treatment of metastatic urothelial carcinoma after accurate diagnosis by immunohistochemistry",

abstract = "Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.",

keywords = "Carbohydrate antigen 19-9, Chemotherapy, S-pancreas-1 antigen, Uroplakin III, Urothelial carcinoma",

author = "Go Makimoto and Hisakazu Nishimori and Reiko Kondo and Hiroyuki Yanai and Morito Sugimoto and Naohiro Oda and Toshio Kubo and Katsuyuki Hotta and Masahiro Tabata and Katsuyuki Kiura and Yoshinobu Maeda",

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year = "2019",

language = "English",

volume = "73",

pages = "279--284",

journal = "Acta medica Okayama",

issn = "0386-300X",

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T1 - Successful treatment of metastatic urothelial carcinoma after accurate diagnosis by immunohistochemistry

AU - Makimoto, Go

AU - Nishimori, Hisakazu

AU - Kondo, Reiko

AU - Yanai, Hiroyuki

AU - Sugimoto, Morito

AU - Oda, Naohiro

AU - Kubo, Toshio

AU - Hotta, Katsuyuki

AU - Tabata, Masahiro

AU - Kiura, Katsuyuki

AU - Maeda, Yoshinobu

PY - 2019

Y1 - 2019

N2 - Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.

AB - Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.

KW - Carbohydrate antigen 19-9

KW - Chemotherapy

KW - S-pancreas-1 antigen

KW - Uroplakin III

KW - Urothelial carcinoma

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SN - 0386-300X

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JO - Acta medica Okayama

JF - Acta medica Okayama

IS - 3

ER -

Successful treatment of metastatic urothelial carcinoma after accurate diagnosis by immunohistochemistry

Abstract

Keywords

ASJC Scopus subject areas

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