Successful vancomycin dose adjustment in a sepsis patient with bacterial meningitis using cystatin C

Masayuki Chuma, Masateru Kondo, Yoshito Zamami, Kenshi Takechi, Mitsuhiro Goda, Naoto Okada, Akitomo Shibata, Mizuho Asada, Jun Oto, Hiroaki Yanagawa, Keisuke Ishizawa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function.

Original languageEnglish
Pages (from-to)365-370
Number of pages6
JournalActa medica Okayama
Volume74
Issue number4
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Bacterial meningitis
  • Cystatin C
  • Sepsis
  • Therapeutic drug monitoring
  • Vancomycin

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology

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