TY - JOUR
T1 - Sulfobetaine (dimethylsulfoniopropionate) and glycine betaine show incompatible involvement in crucial ehrlich ascites carcinoma in mice
AU - Nakajima, Kenji
AU - Nakajima, Yoshiki
AU - Tsujiwaki, Satomi
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Background/Aim: The role of methylation reactions in cancer was examined using the methylating agents, sulfobetaine [dimethylsulfonioproponate (DMSP)], and glycine betaine (GB), in murine crucial Ehrlich ascites carcinoma (EAC) for up to 10 days. Results: DMSP administration in EAC-bearing mice mitigated EAC, while GB administration clearly promoted EAC. However, the immune cell profiles did not differ largely between animals receiving DMSP and those receiving GB. Moreover, DMSP and GB had merely any effects on proliferation of EAC cells in vitro. Injection of DMSP into normal mice interestingly led to macrophage accumulation in the peritoneal cavity in a dose-dependent manner at early rearing. Conclusion: These results indicate that GB promoted EAC by the methylation of cancer promotor gene, whereas DMSP ameliorated EAC by the accumulation of activated macrophages with a rapid response and long life span during cancer progression.
AB - Background/Aim: The role of methylation reactions in cancer was examined using the methylating agents, sulfobetaine [dimethylsulfonioproponate (DMSP)], and glycine betaine (GB), in murine crucial Ehrlich ascites carcinoma (EAC) for up to 10 days. Results: DMSP administration in EAC-bearing mice mitigated EAC, while GB administration clearly promoted EAC. However, the immune cell profiles did not differ largely between animals receiving DMSP and those receiving GB. Moreover, DMSP and GB had merely any effects on proliferation of EAC cells in vitro. Injection of DMSP into normal mice interestingly led to macrophage accumulation in the peritoneal cavity in a dose-dependent manner at early rearing. Conclusion: These results indicate that GB promoted EAC by the methylation of cancer promotor gene, whereas DMSP ameliorated EAC by the accumulation of activated macrophages with a rapid response and long life span during cancer progression.
KW - Activated macrophages
KW - Betaine
KW - Dimethylsulfoniopropionate
KW - Ehrlich ascites carcinoma
KW - Methylation reaction
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M3 - Article
C2 - 25750300
AN - SCOPUS:84924973831
SN - 0250-7005
VL - 35
SP - 1475
EP - 1480
JO - Anticancer research
JF - Anticancer research
IS - 3
ER -
