Sustained tubulointerstitial inflammation in kidney with severe leptospirosis

Keiko Tanaka, Katsuyuki Tanabe, Naoko Nishii, Keiichi Takiue, Hitoshi Sugiyama, Jun Wada

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Leptospirosis is frequently associated with acute kidney injury. Some survivors are known to progress to chronic kidney disease due to sustained tubulointerstitial inflammation. We present a case of severe leptospirosis with acute renal failure. Although antibiotic therapy resolved the infection, moderate renal dysfunction remained. A renal biopsy demonstrated marked inflammatory infiltration in the tubules and interstitium. Many of the inflammatory cells were CD68-positive monocytes/macrophages, predominantly M1 phenotype. An intermediate dose of oral corticosteroids normalized the patient’s serum creatinine levels. We suggest that corticosteroid therapy may be a therapeutic option for some patients with sustained tubulointerstitial nephritis who survive severe leptospirosis.

Original languageEnglish
Pages (from-to)1179-1184
Number of pages6
JournalInternal Medicine
Issue number10
Publication statusPublished - 2017


  • Acute kidney injury
  • Leptospirosis
  • Macrophages

ASJC Scopus subject areas

  • Internal Medicine


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