TY - JOUR
T1 - Synaptic Multivesicular Release in the Cerebellar Cortex
T2 - Its Mechanism and Role in Neural Encoding and Processing
AU - Satake, Shin’Ichiro I.
AU - Inoue, Tsuyoshi
AU - Imoto, Keiji
N1 - Funding Information:
This work was partly supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and the Japan Society for the Promotion of Science.
Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - The number of synaptic vesicles released during fast release plays a major role in determining the strength of postsynaptic response. However, it remains unresolved how the number of vesicles released in response to action potentials is controlled at a single synapse. Recent findings suggest that the Cav2.1 subtype (P/Q-type) of voltage-gated calcium channels is responsible for inducing presynaptic multivesicular release (MVR) at rat cerebellar glutamatergic synapses from granule cells to molecular layer interneurons. The topographical distance from Cav2.1 channels to exocytotic Ca2+ sensors is a critical determinant of MVR. In physiological trains of presynaptic neurons, MVR significantly impacts the excitability of postsynaptic neurons, not only by increasing peak amplitude but also by prolonging decay time of the postsynaptic currents. Therefore, MVR contributes additional complexity to neural encoding and processing in the cerebellar cortex.
AB - The number of synaptic vesicles released during fast release plays a major role in determining the strength of postsynaptic response. However, it remains unresolved how the number of vesicles released in response to action potentials is controlled at a single synapse. Recent findings suggest that the Cav2.1 subtype (P/Q-type) of voltage-gated calcium channels is responsible for inducing presynaptic multivesicular release (MVR) at rat cerebellar glutamatergic synapses from granule cells to molecular layer interneurons. The topographical distance from Cav2.1 channels to exocytotic Ca2+ sensors is a critical determinant of MVR. In physiological trains of presynaptic neurons, MVR significantly impacts the excitability of postsynaptic neurons, not only by increasing peak amplitude but also by prolonging decay time of the postsynaptic currents. Therefore, MVR contributes additional complexity to neural encoding and processing in the cerebellar cortex.
KW - Ca microdomain
KW - Ca2 channel subtype
KW - Excitatory postsynaptic current
KW - Granule cell
KW - Kinetics
KW - Molecular layer interneuron
KW - Paired-pulse ratio
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U2 - 10.1007/s12311-015-0677-5
DO - 10.1007/s12311-015-0677-5
M3 - Review article
C2 - 25971904
AN - SCOPUS:84959488328
SN - 1473-4222
VL - 15
SP - 201
EP - 207
JO - Cerebellum
JF - Cerebellum
IS - 2
ER -