TY - JOUR
T1 - Syntaxin 1 (HPC-1) is associated with chromaffin granules
AU - Tagaya, M.
AU - Toyonaga, S.
AU - Takahashi, M.
AU - Yamamoto, A.
AU - Fujiwara, T.
AU - Akagawa, K.
AU - Moriyama, Y.
AU - Mizushima, S.
PY - 1995
Y1 - 1995
N2 - Syntaxin 1 (HPC-1), a component of the receptor for SNAPs (soluble N- ethylmaleimide-sensitive factor attachment proteins), has been implicated in the docking and fusion of synaptic vesicles with the plasma membrane. It was reported that syntaxin 1 in rat brain and chromaffin cells (PC12) is exclusively located on the plasma membrane (Bennett, M. K., Calakos, N., and Scheller, R. H. (1992) Science 257, 255-259; Sollner, T., Bennett, M. K., Whiteheart, S. W., Scheller, R. H., and Rothman, J. E. (1993) Cell 75, 409- 418). By means of biochemical and morphological analyses, we now show that syntaxin 1 is associated with chromaffin granules in the adrenal medulla. This finding raises the possibility that syntaxin 1 in chromaffin cells is a component of vesicle-SNAP receptor as well as one of target-SNAP receptor on the plasma membrane.
AB - Syntaxin 1 (HPC-1), a component of the receptor for SNAPs (soluble N- ethylmaleimide-sensitive factor attachment proteins), has been implicated in the docking and fusion of synaptic vesicles with the plasma membrane. It was reported that syntaxin 1 in rat brain and chromaffin cells (PC12) is exclusively located on the plasma membrane (Bennett, M. K., Calakos, N., and Scheller, R. H. (1992) Science 257, 255-259; Sollner, T., Bennett, M. K., Whiteheart, S. W., Scheller, R. H., and Rothman, J. E. (1993) Cell 75, 409- 418). By means of biochemical and morphological analyses, we now show that syntaxin 1 is associated with chromaffin granules in the adrenal medulla. This finding raises the possibility that syntaxin 1 in chromaffin cells is a component of vesicle-SNAP receptor as well as one of target-SNAP receptor on the plasma membrane.
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U2 - 10.1074/jbc.270.27.15930
DO - 10.1074/jbc.270.27.15930
M3 - Article
C2 - 7608144
AN - SCOPUS:0029028266
SN - 0021-9258
VL - 270
SP - 15930
EP - 15933
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 27
ER -