Syntaxin 1 (HPC-1) is associated with chromaffin granules

M. Tagaya, S. Toyonaga, M. Takahashi, A. Yamamoto, T. Fujiwara, K. Akagawa, Y. Moriyama, S. Mizushima

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20 Citations (Scopus)


Syntaxin 1 (HPC-1), a component of the receptor for SNAPs (soluble N- ethylmaleimide-sensitive factor attachment proteins), has been implicated in the docking and fusion of synaptic vesicles with the plasma membrane. It was reported that syntaxin 1 in rat brain and chromaffin cells (PC12) is exclusively located on the plasma membrane (Bennett, M. K., Calakos, N., and Scheller, R. H. (1992) Science 257, 255-259; Sollner, T., Bennett, M. K., Whiteheart, S. W., Scheller, R. H., and Rothman, J. E. (1993) Cell 75, 409- 418). By means of biochemical and morphological analyses, we now show that syntaxin 1 is associated with chromaffin granules in the adrenal medulla. This finding raises the possibility that syntaxin 1 in chromaffin cells is a component of vesicle-SNAP receptor as well as one of target-SNAP receptor on the plasma membrane.

Original languageEnglish
Pages (from-to)15930-15933
Number of pages4
JournalJournal of Biological Chemistry
Issue number27
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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