Abstract
Syntaxin 1 (HPC-1), a component of the receptor for SNAPs (soluble N- ethylmaleimide-sensitive factor attachment proteins), has been implicated in the docking and fusion of synaptic vesicles with the plasma membrane. It was reported that syntaxin 1 in rat brain and chromaffin cells (PC12) is exclusively located on the plasma membrane (Bennett, M. K., Calakos, N., and Scheller, R. H. (1992) Science 257, 255-259; Sollner, T., Bennett, M. K., Whiteheart, S. W., Scheller, R. H., and Rothman, J. E. (1993) Cell 75, 409- 418). By means of biochemical and morphological analyses, we now show that syntaxin 1 is associated with chromaffin granules in the adrenal medulla. This finding raises the possibility that syntaxin 1 in chromaffin cells is a component of vesicle-SNAP receptor as well as one of target-SNAP receptor on the plasma membrane.
| Original language | English |
|---|---|
| Pages (from-to) | 15930-15933 |
| Number of pages | 4 |
| Journal | Journal of Biological Chemistry |
| Volume | 270 |
| Issue number | 27 |
| DOIs | |
| Publication status | Published - Jul 7 1995 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
Fingerprint
Dive into the research topics of 'Syntaxin 1 (HPC-1) is associated with chromaffin granules'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS