TY - JOUR
T1 - Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5,7- pentoxocanes and 1,2,4,5-tetroxanes
AU - Kim, Hye Sook
AU - Shibata, Yasuharu
AU - Wataya, Yusuke
AU - Tsuchiya, Kaoru
AU - Masuyama, Araki
AU - Nojima, Masatomo
PY - 1999/7/15
Y1 - 1999/7/15
N2 - A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic peroxides, the steric and electronic effects of the substituents attached to the peroxide ring exert a remarkable influence on the antimalarial activity. For some cyclic peroxides, which were found to be highly effective in vitro, the study in vivo has been also conducted.
AB - A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic peroxides, the steric and electronic effects of the substituents attached to the peroxide ring exert a remarkable influence on the antimalarial activity. For some cyclic peroxides, which were found to be highly effective in vitro, the study in vivo has been also conducted.
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U2 - 10.1021/jm990014j
DO - 10.1021/jm990014j
M3 - Article
C2 - 10411480
AN - SCOPUS:0033566212
SN - 0022-2623
VL - 42
SP - 2604
EP - 2609
JO - Journal of medicinal chemistry
JF - Journal of medicinal chemistry
IS - 14
ER -