TY - JOUR
T1 - Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes
AU - Kim, H. S.
AU - Nagai, Y.
AU - Ono, K.
AU - Begum, K.
AU - Wataya, Y.
AU - Hamada, Y.
AU - Tsuchiya, K.
AU - Masuyama, A.
AU - Nojima, M.
AU - McCullough, K. J.
PY - 2001/7/5
Y1 - 2001/7/5
N2 - CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n-dihaloalkanes (n = 3-8) provided the corresponding medium-sized 1,2,4,5-tetraoxacycloalkanes 4-8 in moderate yields. Subsequent evaluation of the antimalarial activity of the cyclic peroxides 4-8 in vitro and in vivo revealed that 1,2,6,7-tetraoxaspiro[7.11]nonadecane 4a has considerable potential as a new, inexpensive, and potent antimalarial drug.
AB - CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n-dihaloalkanes (n = 3-8) provided the corresponding medium-sized 1,2,4,5-tetraoxacycloalkanes 4-8 in moderate yields. Subsequent evaluation of the antimalarial activity of the cyclic peroxides 4-8 in vitro and in vivo revealed that 1,2,6,7-tetraoxaspiro[7.11]nonadecane 4a has considerable potential as a new, inexpensive, and potent antimalarial drug.
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U2 - 10.1021/jm010026g
DO - 10.1021/jm010026g
M3 - Article
C2 - 11428929
AN - SCOPUS:0035811454
SN - 0022-2623
VL - 44
SP - 2357
EP - 2361
JO - Journal of medicinal chemistry
JF - Journal of medicinal chemistry
IS - 14
ER -