Synthesis and antimicrobial activity of unnatural (-)-antimycin A3 and its analog

Hitoshi Kondo; Takayuki Oritani; Hiromasa Kiyota

doi:10.1515/hc.2000.6.3.211

Synthesis and antimicrobial activity of unnatural (-)-antimycin A₃ and its analog

Hitoshi Kondo, Takayuki Oritani, Hiromasa Kiyota

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Unnatural enantiomer of adilactone antibiotic (-)-antimycin A₃ and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A₃ and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A₃ is also achieved.

Original language	English
Pages (from-to)	211-214
Number of pages	4
Journal	Heterocyclic Communications
Volume	6
Issue number	3
DOIs	https://doi.org/10.1515/hc.2000.6.3.211
Publication status	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1515/hc.2000.6.3.211

Cite this

@article{3da5c38273cd4ec39316949dba207d95,

title = "Synthesis and antimicrobial activity of unnatural (-)-antimycin A3 and its analog",

abstract = "Unnatural enantiomer of adilactone antibiotic (-)-antimycin A3 and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A3 and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A3 is also achieved.",

author = "Hitoshi Kondo and Takayuki Oritani and Hiromasa Kiyota",

year = "2000",

doi = "10.1515/hc.2000.6.3.211",

language = "English",

volume = "6",

pages = "211--214",

journal = "Heterocyclic Communications",

issn = "0793-0283",

publisher = "Walter de Gruyter GmbH & Co. KG",

number = "3",

}

TY - JOUR

T1 - Synthesis and antimicrobial activity of unnatural (-)-antimycin A3 and its analog

AU - Kondo, Hitoshi

AU - Oritani, Takayuki

AU - Kiyota, Hiromasa

PY - 2000

Y1 - 2000

N2 - Unnatural enantiomer of adilactone antibiotic (-)-antimycin A3 and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A3 and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A3 is also achieved.

AB - Unnatural enantiomer of adilactone antibiotic (-)-antimycin A3 and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A3 and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A3 is also achieved.

UR - http://www.scopus.com/inward/record.url?scp=0034379262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034379262&partnerID=8YFLogxK

U2 - 10.1515/hc.2000.6.3.211

DO - 10.1515/hc.2000.6.3.211

M3 - Article

AN - SCOPUS:0034379262

SN - 0793-0283

VL - 6

SP - 211

EP - 214

JO - Heterocyclic Communications

JF - Heterocyclic Communications

IS - 3

ER -

Synthesis and antimicrobial activity of unnatural (-)-antimycin A₃ and its analog

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this