Synthesis and antinematodal activity of 3-n-alkylphenols

Kazuto Takaishi, Yohannes Alen, Kazuyoshi Kawazu, Naomichi Baba, Shuhei Nakajima

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Several 3-alkylphenols including 3-undecylphenol, which was isolated from a Sumatran rainforest plant, were synthesized to investigate their antinematodal activity against the phytopathogenic nematodes, Bursapherencus xylophilus. A three-step synthesis involving the treatment of 2-cyclohexen-1-one with the Grignard reagent, oxidation of the resulting 1-alkyl-2-cyclohexen-1-ol and subsequent aromatization of 3-alkyl-2-cyclohexen-1-one successfully afforded such phenols. Among the 3-alkylphenols, 3-nonylphenol showed the highest activity, while 3-decylphenol and 3-undecylphenol also showed high activity.

Original languageEnglish
Pages (from-to)2398-2400
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number11
Publication statusPublished - Nov 2004


  • 3-alkylphenols
  • 3-nonylphenol
  • 3-undecylphenol
  • Antinematodal activity
  • Bursapherencus xylophilus

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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