Synthesis and antitumor activity of 7-(w-glycosylamino)-indolo[3,2-6]quinolines

Yasuo Takeuchi; Ming rong Chang; Kuniko Hashigaki; Masatoshi Yamato

doi:10.1248/cpb.39.1629

Synthesis and antitumor activity of 7-(w-glycosylamino)-indolo[3,2-6]quinolines

Yasuo Takeuchi, Ming rong Chang, Kuniko Hashigaki, Masatoshi Yamato

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Novel indolo[3,2-6]quinolines (l d-g), introduced at the 7-position with an N- glycosylamino group, were prepared and their antitumor activities against leukemia P388 in mice were examined. The N-Galactopyranosylamino derivative (le) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C > 333%, cure 5/6) than lead compound la.

Original language	English
Pages (from-to)	1629-1631
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	39
Issue number	6
DOIs	https://doi.org/10.1248/cpb.39.1629
Publication status	Published - 1991

Keywords

2-6]quinoline glycosylation antitumor activity intercalation P388 leukemia
indolo[3

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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abstract = "Novel indolo[3,2-6]quinolines (l d-g), introduced at the 7-position with an N- glycosylamino group, were prepared and their antitumor activities against leukemia P388 in mice were examined. The N-Galactopyranosylamino derivative (le) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C > 333%, cure 5/6) than lead compound la.",

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author = "Yasuo Takeuchi and Chang, {Ming rong} and Kuniko Hashigaki and Masatoshi Yamato",

year = "1991",

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AU - Takeuchi, Yasuo

AU - Chang, Ming rong

AU - Hashigaki, Kuniko

AU - Yamato, Masatoshi

PY - 1991

Y1 - 1991

N2 - Novel indolo[3,2-6]quinolines (l d-g), introduced at the 7-position with an N- glycosylamino group, were prepared and their antitumor activities against leukemia P388 in mice were examined. The N-Galactopyranosylamino derivative (le) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C > 333%, cure 5/6) than lead compound la.

AB - Novel indolo[3,2-6]quinolines (l d-g), introduced at the 7-position with an N- glycosylamino group, were prepared and their antitumor activities against leukemia P388 in mice were examined. The N-Galactopyranosylamino derivative (le) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C > 333%, cure 5/6) than lead compound la.

KW - 2-6]quinoline glycosylation antitumor activity intercalation P388 leukemia

KW - indolo[3

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Synthesis and antitumor activity of 7-(w-glycosylamino)-indolo[3,2-6]quinolines

Abstract

Keywords

ASJC Scopus subject areas

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