Synthesis and Antitumor Activity of Fused Quinoline Derivatives: III: 1,2) Novel N-Glycosylamino-indolo[ 3,2-b]quinolines

Yasuo Takeuchi; Ming rong Chang; Kuniko Hashigaki; Tazuko Tashiro; Masatoshi Yamato; Takashi Tsuruo; Shigeru Tsukagoshi

doi:10.1248/cpb.40.1481

Synthesis and Antitumor Activity of Fused Quinoline Derivatives: III: ^1,2) Novel N-Glycosylamino-indolo[ 3,2-b]quinolines

Yasuo Takeuchi, Ming rong Chang, Kuniko Hashigaki, Tazuko Tashiro, Masatoshi Yamato, Takashi Tsuruo, Shigeru Tsukagoshi

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Novel indolo[3,2-£]quinolines (lb—k), having a nitro, amino, acetamido, methanesulfonamido, or glycosylamino group at the 2, 7, or 8-position, were prepared and their antitumor activities against P388 leukemia in mice were examined. The 7-galactopyranosylamino derivative (lg) showed the most potent activity (optimal dose = 25 mg/kg, T/C>333%, cure rate 5/6).

Original language	English
Pages (from-to)	1481-1485
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	40
Issue number	6
DOIs	https://doi.org/10.1248/cpb.40.1481
Publication status	Published - 1992

Keywords

P388 leukemia
antitumor activity
glycosylation
indolo[3,2-b]quinoline

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.40.1481

Cite this

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title = "Synthesis and Antitumor Activity of Fused Quinoline Derivatives: III: 1,2) Novel N-Glycosylamino-indolo[ 3,2-b]quinolines",

abstract = "Novel indolo[3,2-£]quinolines (lb—k), having a nitro, amino, acetamido, methanesulfonamido, or glycosylamino group at the 2, 7, or 8-position, were prepared and their antitumor activities against P388 leukemia in mice were examined. The 7-galactopyranosylamino derivative (lg) showed the most potent activity (optimal dose = 25 mg/kg, T/C>333%, cure rate 5/6).",

keywords = "P388 leukemia, antitumor activity, glycosylation, indolo[3,2-b]quinoline",

author = "Yasuo Takeuchi and Chang, {Ming rong} and Kuniko Hashigaki and Tazuko Tashiro and Masatoshi Yamato and Takashi Tsuruo and Shigeru Tsukagoshi",

year = "1992",

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journal = "Chemical and Pharmaceutical Bulletin",

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T1 - Synthesis and Antitumor Activity of Fused Quinoline Derivatives

T2 - III: 1,2) Novel N-Glycosylamino-indolo[ 3,2-b]quinolines

AU - Takeuchi, Yasuo

AU - Chang, Ming rong

AU - Hashigaki, Kuniko

AU - Tashiro, Tazuko

AU - Yamato, Masatoshi

AU - Tsuruo, Takashi

AU - Tsukagoshi, Shigeru

PY - 1992

Y1 - 1992

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AB - Novel indolo[3,2-£]quinolines (lb—k), having a nitro, amino, acetamido, methanesulfonamido, or glycosylamino group at the 2, 7, or 8-position, were prepared and their antitumor activities against P388 leukemia in mice were examined. The 7-galactopyranosylamino derivative (lg) showed the most potent activity (optimal dose = 25 mg/kg, T/C>333%, cure rate 5/6).

KW - P388 leukemia

KW - antitumor activity

KW - glycosylation

KW - indolo[3,2-b]quinoline

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