Synthesis and Antitumor Activity of Tropolone Derivatives. 5

Masatoshi Yamato; Kuniko Hashigaki; Junko Sakai; Yasuo Takeuchi; Shigeru Tsukagoshi; Tazuko Tashiro; Takashi Tsuruo

doi:10.1021/jm00390a022

Synthesis and Antitumor Activity of Tropolone Derivatives. 5

Masatoshi Yamato, Kuniko Hashigaki, Junko Sakai, Yasuo Takeuchi, Shigeru Tsukagoshi, Tazuko Tashiro, Takashi Tsuruo

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

As part of a study on the structure-activity relationship of antitumor-active tropolone derivatives, a series of bistropone analogues, related to potently active bistropolone la, were synthesized and tested for their antitumor activity in in vitro (KB cell) and in vivo (leukemia P388 in mice) systems. The methoxytropones 3 and 5, hydroxytropothione 10, and (N-methylamino)tropones 12 and 13 were inactive in both systems. Methoxytropone 6 exhibited weak activity, whose potency was equal to that of monotropolone 2a.

Original language	English
Pages (from-to)	1245-1248
Number of pages	4
Journal	Journal of medicinal chemistry
Volume	30
Issue number	7
DOIs	https://doi.org/10.1021/jm00390a022
Publication status	Published - Jul 1 1987

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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abstract = "As part of a study on the structure-activity relationship of antitumor-active tropolone derivatives, a series of bistropone analogues, related to potently active bistropolone la, were synthesized and tested for their antitumor activity in in vitro (KB cell) and in vivo (leukemia P388 in mice) systems. The methoxytropones 3 and 5, hydroxytropothione 10, and (N-methylamino)tropones 12 and 13 were inactive in both systems. Methoxytropone 6 exhibited weak activity, whose potency was equal to that of monotropolone 2a.",

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AU - Yamato, Masatoshi

AU - Hashigaki, Kuniko

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AU - Takeuchi, Yasuo

AU - Tsukagoshi, Shigeru

AU - Tashiro, Tazuko

AU - Tsuruo, Takashi

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Synthesis and Antitumor Activity of Tropolone Derivatives. 5

Abstract

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