Synthesis and biological evaluation of 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues

Qian Cheng, Hiromasa Kiyota, Marina Yamaguchi, Tohru Horiguchi, Takayuki Oritani

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Three novel 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues were synthesized through a convenient route that employed hydroboration-amination and intramolecular SN2-type substitution reaction from a natural taxoid taxinine. All analogues have been tested for cytotoxicity against three human tumor cell lines. None of them showed remarkable cytotoxicity compared to paclitaxel against tested tumor cell lines.

Original languageEnglish
Pages (from-to)1075-1077
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number6
Publication statusPublished - Mar 24 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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