Synthesis and chemiluminescent activity of pyridazino[4,5-b]indole-1,4(2H,3H)-diones

Masateru Kurumi, Kenji Sasaki, Hiroko Takata, Taiji Nakayama

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)


    Substituted and non-substituted anilines were transformed to the corresponding triazole derivatives, which were converted to dimethyl indole-2,3-dicarboxylates by photocyclization. The reaction of diester with hydrazine hydrate gave 1,2,3,4-tetrahydro-5H-pyridazino[4,5-b]indole-1,4(2H,3H)-diones (5). Some of compounds (5) were found to have chemiluminescent activity in a similarly to luminol in the presence of hydrogen peroxide and peroxidase in a basic solution.

    Original languageEnglish
    Pages (from-to)2809-2819
    Number of pages11
    Issue number12
    Publication statusPublished - Dec 1 2000

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Pharmacology
    • Organic Chemistry


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