Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes

Yoshiaki Hamada, Hidekazu Tokuhara, Araki Masuyama, Masatomo Nojima, Hye Sook Kim, Kanako Ono, Naoki Ogura, Yusuke Wataya

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)


Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).

Original languageEnglish
Pages (from-to)1374-1378
Number of pages5
JournalJournal of medicinal chemistry
Issue number6
Publication statusPublished - Mar 14 2002

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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