Synthesis of actiketal, a glutarimide antibiotic

Hiromasa Kiyota; Yuko Shimizu; Takayuki Oritani

doi:10.1016/S0040-4039(00)00928-X

Synthesis of actiketal, a glutarimide antibiotic

Hiromasa Kiyota, Yuko Shimizu, Takayuki Oritani

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The first synthesis of actiketal (RK-441S), an antibiotic from Streptomyces pulveraceus subsp. epiderstagenes, was achieved from 5,7- dimethylbenzofuran and dimethyl glutaconate via palladium-assisted coupling reaction as a key step. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	5887-5890
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	31
DOIs	https://doi.org/10.1016/S0040-4039(00)00928-X
Publication status	Published - Jul 29 2000
Externally published	Yes

Keywords

Acetals
Antibiotics
Glutarimides
Polyketides

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)00928-X

Cite this

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abstract = "The first synthesis of actiketal (RK-441S), an antibiotic from Streptomyces pulveraceus subsp. epiderstagenes, was achieved from 5,7- dimethylbenzofuran and dimethyl glutaconate via palladium-assisted coupling reaction as a key step. (C) 2000 Elsevier Science Ltd.",

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AU - Shimizu, Yuko

AU - Oritani, Takayuki

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AB - The first synthesis of actiketal (RK-441S), an antibiotic from Streptomyces pulveraceus subsp. epiderstagenes, was achieved from 5,7- dimethylbenzofuran and dimethyl glutaconate via palladium-assisted coupling reaction as a key step. (C) 2000 Elsevier Science Ltd.

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KW - Antibiotics

KW - Glutarimides

KW - Polyketides

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ER -

Synthesis of actiketal, a glutarimide antibiotic

Abstract

Keywords

ASJC Scopus subject areas

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