Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption

Hatsuo Yamamura; Yuuki Sugiyama; Kensuke Murata; Takanori Yokoi; Ryuji Kurata; Atsushi Miyagawa; Kenji Sakamoto; Keiko Komagoe; Tsuyoshi Inoue; Takashi Katsu

doi:10.1039/c3cc49543d

Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption

Hatsuo Yamamura, Yuuki Sugiyama, Kensuke Murata, Takanori Yokoi, Ryuji Kurata, Atsushi Miyagawa, Kenji Sakamoto, Keiko Komagoe, Tsuyoshi Inoue, Takashi Katsu

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Cyclodextrin derivatives are synthesized as membrane-disrupting agents via a microwave-assisted Huisgen reaction. Their ability to permeabilize bacterial membranes depends on the amino substituents and an appropriate balance of hydrophobicity and hydrophilicity, thus enabling the preparation of derivatives with selective toxicity against bacteria.

Original language	English
Pages (from-to)	5444-5446
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	41
DOIs	https://doi.org/10.1039/c3cc49543d
Publication status	Published - Apr 24 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Cyclodextrin derivatives are synthesized as membrane-disrupting agents via a microwave-assisted Huisgen reaction. Their ability to permeabilize bacterial membranes depends on the amino substituents and an appropriate balance of hydrophobicity and hydrophilicity, thus enabling the preparation of derivatives with selective toxicity against bacteria.",

author = "Hatsuo Yamamura and Yuuki Sugiyama and Kensuke Murata and Takanori Yokoi and Ryuji Kurata and Atsushi Miyagawa and Kenji Sakamoto and Keiko Komagoe and Tsuyoshi Inoue and Takashi Katsu",

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T1 - Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption

AU - Yamamura, Hatsuo

AU - Sugiyama, Yuuki

AU - Murata, Kensuke

AU - Yokoi, Takanori

AU - Kurata, Ryuji

AU - Miyagawa, Atsushi

AU - Sakamoto, Kenji

AU - Komagoe, Keiko

AU - Inoue, Tsuyoshi

AU - Katsu, Takashi

PY - 2014/4/24

Y1 - 2014/4/24

N2 - Cyclodextrin derivatives are synthesized as membrane-disrupting agents via a microwave-assisted Huisgen reaction. Their ability to permeabilize bacterial membranes depends on the amino substituents and an appropriate balance of hydrophobicity and hydrophilicity, thus enabling the preparation of derivatives with selective toxicity against bacteria.

AB - Cyclodextrin derivatives are synthesized as membrane-disrupting agents via a microwave-assisted Huisgen reaction. Their ability to permeabilize bacterial membranes depends on the amino substituents and an appropriate balance of hydrophobicity and hydrophilicity, thus enabling the preparation of derivatives with selective toxicity against bacteria.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption

Abstract

ASJC Scopus subject areas

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