Synthesis of blood compatible PDMS-based organic-inorganic hybrid coatings

Takeshi Yabuta; Kanji Tsuru; Satoshi Hayakawa; Akiyoshi Osaka

doi:10.1023/B:JSST.0000048002.65187.3a

Synthesis of blood compatible PDMS-based organic-inorganic hybrid coatings

Takeshi Yabuta, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

PDMS-TiO₂ hybrid coating sols were prepared from silanol-terminated polydimethylsiloxane and titanium tetraisopropoxide through sol-gel process. The coating sols were developed on stainless steel substrate with dip-coating technique. The surface structure of the hybrid coating was characterized by Fourier transform infrared (FT-IR) analysis, contact angle, and surface free energy on the hybrid coating. Blood compatibility was also evaluated in terms of blood clotting time and platelet adhesion. The hybrid coatings have high contact angles and low surface free energies compared to coating-free metal surface. The blood clotting properties were not affected by the hybrid coatings but the platelet adhesion was depressed to less than 1/20 as much as that for the coating-free substrate.

Original language	English
Pages (from-to)	273-276
Number of pages	4
Journal	Journal of Sol-Gel Science and Technology
Volume	31
Issue number	1-3 SPEC.ISS.
DOIs	https://doi.org/10.1023/B:JSST.0000048002.65187.3a
Publication status	Published - Aug 2004

Keywords

Blood clotting property
Blood compatibility
Organic-inorganic hybrid coating
Platelet adhesion

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Biomaterials
Condensed Matter Physics
Materials Chemistry

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10.1023/B:JSST.0000048002.65187.3a

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title = "Synthesis of blood compatible PDMS-based organic-inorganic hybrid coatings",

abstract = "PDMS-TiO2 hybrid coating sols were prepared from silanol-terminated polydimethylsiloxane and titanium tetraisopropoxide through sol-gel process. The coating sols were developed on stainless steel substrate with dip-coating technique. The surface structure of the hybrid coating was characterized by Fourier transform infrared (FT-IR) analysis, contact angle, and surface free energy on the hybrid coating. Blood compatibility was also evaluated in terms of blood clotting time and platelet adhesion. The hybrid coatings have high contact angles and low surface free energies compared to coating-free metal surface. The blood clotting properties were not affected by the hybrid coatings but the platelet adhesion was depressed to less than 1/20 as much as that for the coating-free substrate.",

keywords = "Blood clotting property, Blood compatibility, Organic-inorganic hybrid coating, Platelet adhesion",

author = "Takeshi Yabuta and Kanji Tsuru and Satoshi Hayakawa and Akiyoshi Osaka",

note = "Funding Information: This study was supported by the Industrial Technology Research Grant Program (02A47022a) from the New Energy and Industrial Technology Development Organization (NEDO) of Japan. Author thanks the Encouragement Research Grant from the Graduate School of Natural Science and Technology in Okayama University. The support by the Research Grant from the Venture Business Laboratory of Okayama University is also acknowledged.",

year = "2004",

month = aug,

doi = "10.1023/B:JSST.0000048002.65187.3a",

language = "English",

volume = "31",

pages = "273--276",

journal = "Journal of Sol-Gel Science and Technology",

issn = "0928-0707",

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number = "1-3 SPEC.ISS.",

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T1 - Synthesis of blood compatible PDMS-based organic-inorganic hybrid coatings

AU - Yabuta, Takeshi

AU - Tsuru, Kanji

AU - Hayakawa, Satoshi

AU - Osaka, Akiyoshi

N1 - Funding Information: This study was supported by the Industrial Technology Research Grant Program (02A47022a) from the New Energy and Industrial Technology Development Organization (NEDO) of Japan. Author thanks the Encouragement Research Grant from the Graduate School of Natural Science and Technology in Okayama University. The support by the Research Grant from the Venture Business Laboratory of Okayama University is also acknowledged.

PY - 2004/8

Y1 - 2004/8

N2 - PDMS-TiO2 hybrid coating sols were prepared from silanol-terminated polydimethylsiloxane and titanium tetraisopropoxide through sol-gel process. The coating sols were developed on stainless steel substrate with dip-coating technique. The surface structure of the hybrid coating was characterized by Fourier transform infrared (FT-IR) analysis, contact angle, and surface free energy on the hybrid coating. Blood compatibility was also evaluated in terms of blood clotting time and platelet adhesion. The hybrid coatings have high contact angles and low surface free energies compared to coating-free metal surface. The blood clotting properties were not affected by the hybrid coatings but the platelet adhesion was depressed to less than 1/20 as much as that for the coating-free substrate.

AB - PDMS-TiO2 hybrid coating sols were prepared from silanol-terminated polydimethylsiloxane and titanium tetraisopropoxide through sol-gel process. The coating sols were developed on stainless steel substrate with dip-coating technique. The surface structure of the hybrid coating was characterized by Fourier transform infrared (FT-IR) analysis, contact angle, and surface free energy on the hybrid coating. Blood compatibility was also evaluated in terms of blood clotting time and platelet adhesion. The hybrid coatings have high contact angles and low surface free energies compared to coating-free metal surface. The blood clotting properties were not affected by the hybrid coatings but the platelet adhesion was depressed to less than 1/20 as much as that for the coating-free substrate.

KW - Blood clotting property

KW - Blood compatibility

KW - Organic-inorganic hybrid coating

KW - Platelet adhesion

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JF - Journal of Sol-Gel Science and Technology

IS - 1-3 SPEC.ISS.

ER -

Synthesis of blood compatible PDMS-based organic-inorganic hybrid coatings

Abstract

Keywords

ASJC Scopus subject areas

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