Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances

Seisuke Takashima; Y. Kusudo; S. Takemoto; K. Tsuru; S. Hayakawa; A. Osaka

Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances

Seisuke Takashima, Y. Kusudo, S. Takemoto, K. Tsuru, S. Hayakawa, A. Osaka

Research output: Contribution to journal › Conference article › peer-review

Abstract

Hydroxyapatite (HAP) and carbonate-hydroxy apatite (CAP5 and CAP15) were synthesized under the flow of N₂ containing 0%, 5%, or 15% CO₂ by wet chemical method, and subsequently calcined at 105-700°C. Infrared analysis showed that carbonate ions substituted PO₄^3- and OH^- sites. The clotting characteristics for the fresh mixed plasma contacted with the samples indicated that CAP had better blood compatibility than HAP. The protein adsorption activity was evaluated by contacting with the model saline containing bovine serum albumin (BSA) and β₂-microgloburin (β₂-MG). CAP15 calcined below 600°C adsorbed the lowest fraction of BSA (9%) whereas it adsorbed the highest fraction of β₂-MG (47%). It was concluded that the selective adsorption activity against β₂-MG was related to the carbonate ions incorporated in hydroxyapatite.

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	Key Engineering Materials
Volume	218-220
Publication status	Published - 2002
Event	14th International Symposium on Ceramics in Medicine-Annual Meeting of the International Society for Ceramics in Medicine BIOCERAMICS'01 (ISCM) - Palm Springs, CA, United States Duration: Nov 14 2001 → Nov 17 2001

Keywords

Blood Compatibility
Bovine Serum Albumin
Carbonate-Hydroxy Apatite
Hydroxyapatite
β-Microgloburin

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances",

abstract = "Hydroxyapatite (HAP) and carbonate-hydroxy apatite (CAP5 and CAP15) were synthesized under the flow of N2 containing 0%, 5%, or 15% CO2 by wet chemical method, and subsequently calcined at 105-700°C. Infrared analysis showed that carbonate ions substituted PO43- and OH- sites. The clotting characteristics for the fresh mixed plasma contacted with the samples indicated that CAP had better blood compatibility than HAP. The protein adsorption activity was evaluated by contacting with the model saline containing bovine serum albumin (BSA) and β2-microgloburin (β2-MG). CAP15 calcined below 600°C adsorbed the lowest fraction of BSA (9%) whereas it adsorbed the highest fraction of β2-MG (47%). It was concluded that the selective adsorption activity against β2-MG was related to the carbonate ions incorporated in hydroxyapatite.",

keywords = "Blood Compatibility, Bovine Serum Albumin, Carbonate-Hydroxy Apatite, Hydroxyapatite, β-Microgloburin",

author = "Seisuke Takashima and Y. Kusudo and S. Takemoto and K. Tsuru and S. Hayakawa and A. Osaka",

year = "2002",

language = "English",

volume = "218-220",

pages = "175--178",

journal = "Key Engineering Materials",

issn = "1013-9826",

publisher = "Trans Tech Publications Ltd",

note = "14th International Symposium on Ceramics in Medicine-Annual Meeting of the International Society for Ceramics in Medicine BIOCERAMICS'01 (ISCM) ; Conference date: 14-11-2001 Through 17-11-2001",

}

TY - JOUR

T1 - Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances

AU - Takashima, Seisuke

AU - Kusudo, Y.

AU - Takemoto, S.

AU - Tsuru, K.

AU - Hayakawa, S.

AU - Osaka, A.

PY - 2002

Y1 - 2002

N2 - Hydroxyapatite (HAP) and carbonate-hydroxy apatite (CAP5 and CAP15) were synthesized under the flow of N2 containing 0%, 5%, or 15% CO2 by wet chemical method, and subsequently calcined at 105-700°C. Infrared analysis showed that carbonate ions substituted PO43- and OH- sites. The clotting characteristics for the fresh mixed plasma contacted with the samples indicated that CAP had better blood compatibility than HAP. The protein adsorption activity was evaluated by contacting with the model saline containing bovine serum albumin (BSA) and β2-microgloburin (β2-MG). CAP15 calcined below 600°C adsorbed the lowest fraction of BSA (9%) whereas it adsorbed the highest fraction of β2-MG (47%). It was concluded that the selective adsorption activity against β2-MG was related to the carbonate ions incorporated in hydroxyapatite.

AB - Hydroxyapatite (HAP) and carbonate-hydroxy apatite (CAP5 and CAP15) were synthesized under the flow of N2 containing 0%, 5%, or 15% CO2 by wet chemical method, and subsequently calcined at 105-700°C. Infrared analysis showed that carbonate ions substituted PO43- and OH- sites. The clotting characteristics for the fresh mixed plasma contacted with the samples indicated that CAP had better blood compatibility than HAP. The protein adsorption activity was evaluated by contacting with the model saline containing bovine serum albumin (BSA) and β2-microgloburin (β2-MG). CAP15 calcined below 600°C adsorbed the lowest fraction of BSA (9%) whereas it adsorbed the highest fraction of β2-MG (47%). It was concluded that the selective adsorption activity against β2-MG was related to the carbonate ions incorporated in hydroxyapatite.

KW - Blood Compatibility

KW - Bovine Serum Albumin

KW - Carbonate-Hydroxy Apatite

KW - Hydroxyapatite

KW - β-Microgloburin

UR - http://www.scopus.com/inward/record.url?scp=18144440413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18144440413&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:18144440413

SN - 1013-9826

VL - 218-220

SP - 175

EP - 178

JO - Key Engineering Materials

JF - Key Engineering Materials

T2 - 14th International Symposium on Ceramics in Medicine-Annual Meeting of the International Society for Ceramics in Medicine BIOCERAMICS'01 (ISCM)

Y2 - 14 November 2001 through 17 November 2001

ER -

Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances

Abstract

Keywords

ASJC Scopus subject areas

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