Synthesis of D/L-febrifugine and D/L-isofebrifugine

Yasuo Takeuchi, Mayumi Hattori, Hitoshi Abe, Takashi Harayama

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Racemic compounds (1 and 2) of the antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized using an unusual Claisen rearrangement of allyl enol ether 6 and the stereoselective reduction of 2- allylpiperid-3-one 8. This method is widely applicable to the synthesis of febirifugine derivatives.

Original languageEnglish
Pages (from-to)1814-1818
Number of pages5
Issue number10
Publication statusPublished - Jan 1 1999


  • Antimalarial agent
  • Claisen rearrangement
  • Febrifugine
  • Isofebrifugine
  • Stereoselective reduction

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


Dive into the research topics of 'Synthesis of D/L-febrifugine and D/L-isofebrifugine'. Together they form a unique fingerprint.

Cite this