Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene

Takuya Kumamoto; Naho Aoyama; Satoko Nakano; Tsutomu Ishikawa; Shizuo Narimatsu

doi:10.1016/S0957-4166(01)00122-7

Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene

Takuya Kumamoto, Naho Aoyama, Satoko Nakano, Tsutomu Ishikawa, Shizuo Narimatsu

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Both (R)- and (S)-enantiomers of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%.

Original language	English
Pages (from-to)	791-795
Number of pages	5
Journal	Tetrahedron Asymmetry
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/S0957-4166(01)00122-7
Publication status	Published - Apr 2 2001

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1016/S0957-4166(01)00122-7

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title = "Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene",

abstract = "Both (R)- and (S)-enantiomers of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%.",

author = "Takuya Kumamoto and Naho Aoyama and Satoko Nakano and Tsutomu Ishikawa and Shizuo Narimatsu",

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T1 - Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene

AU - Kumamoto, Takuya

AU - Aoyama, Naho

AU - Nakano, Satoko

AU - Ishikawa, Tsutomu

AU - Narimatsu, Shizuo

PY - 2001/4/2

Y1 - 2001/4/2

N2 - Both (R)- and (S)-enantiomers of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%.

AB - Both (R)- and (S)-enantiomers of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%.

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U2 - 10.1016/S0957-4166(01)00122-7

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JO - Tetrahedron Asymmetry

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Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene

Abstract

ASJC Scopus subject areas

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