Synthesis of glaziovianin A: A potent antitumor isoflavone

Ichiro Hayakawa; Akiyuki Ikedo; Hideo Kigoshi

doi:10.1246/cl.2007.1382

Synthesis of glaziovianin A: A potent antitumor isoflavone

Ichiro Hayakawa, Akiyuki Ikedo, Hideo Kigoshi

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Glaziovianin A (1) is a novel isoflavone derivative isolated from the leaves of the Brazilian tree Astelia glazioviana. Glaziovianin A (1) showed cytotoxic activity and was suggested to be an inhibitor of tubulin polymerization. We achieved the total synthesis of glaziovianin A (1) by using the Suzuki-Miyaura coupling as a key step.

Original language	English
Pages (from-to)	1382-1383
Number of pages	2
Journal	Chemistry Letters
Volume	36
Issue number	11
DOIs	https://doi.org/10.1246/cl.2007.1382
Publication status	Published - Nov 5 2007
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2007.1382

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abstract = "Glaziovianin A (1) is a novel isoflavone derivative isolated from the leaves of the Brazilian tree Astelia glazioviana. Glaziovianin A (1) showed cytotoxic activity and was suggested to be an inhibitor of tubulin polymerization. We achieved the total synthesis of glaziovianin A (1) by using the Suzuki-Miyaura coupling as a key step.",

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AU - Kigoshi, Hideo

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AB - Glaziovianin A (1) is a novel isoflavone derivative isolated from the leaves of the Brazilian tree Astelia glazioviana. Glaziovianin A (1) showed cytotoxic activity and was suggested to be an inhibitor of tubulin polymerization. We achieved the total synthesis of glaziovianin A (1) by using the Suzuki-Miyaura coupling as a key step.

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Synthesis of glaziovianin A: A potent antitumor isoflavone

Abstract

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