Synthesis of hydroxyapatite contining manganese and its evaluation of biocompatibility

Wataru Fujitani, Yoshinosuke Hamada, Naomasa Kawaguchi, Seiji Mori, Kiyoshi Daito, Ayako Uchinaka, Takuya Matsumoto, Yoshihisa Kojima, Michiharu Daito, Takayoshi Nakano, Nariaki Matsuura

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Biomaterials made using hydroxyapatite (HAp) and calcium phosphates, which are inorganic components of hard tissues, have been developed to fill bone defects caused by various diseases. A biomaterial of HAp containing collagen, an organic component of bone, has also been developed. However, the physical and biological functions of these bone biomaterials remain inadequate. Focusing on Zinc(Zn) and Manganese(Mn) ions out of the divalent cations involved in the ac- tivity of integrins, which are molecules existing in cell membranes, we synthesized three kinds of inorganic biomaterials-pure HAp, Zn-containing HAp (Zn-HAp), and Mn-containing HAp (Mn-HAp)-by a wet process, These three kinds of HAp powders were formed into pellets of 6mm diameter and 1mm thickness and their bio-adaptability was investigated. In vitro experiments using osteoblast-like cells (MC3T3E1) demonstrated that Mn-HAp showed higher cell adhesion potential than pure HAp, indicating that Mn addition improves biore- sponses. This may be because Mn ions eluted from Mn-HAp pellets activated integrins, which are closely related to the cell adhesion potential of MC3T3E1 cells to the surface of the pellets.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalNano Biomedicine
Issue number1
Publication statusPublished - 2010
Externally publishedYes


  • Biocompatibility
  • Hydroxyapatite(HAp)
  • Manganese

ASJC Scopus subject areas

  • Biomedical Engineering


Dive into the research topics of 'Synthesis of hydroxyapatite contining manganese and its evaluation of biocompatibility'. Together they form a unique fingerprint.

Cite this