Synthesis of lipid derivatives of pyrrole polyamide and their biological activity

Masahiko Yamamoto; Changjin Zhu; Lui Yi; Zheng Rong; Yoshie Miura; Minoru Izumi; Shuhei Nakajima; Ken Ichi Tanamoto; Sakayu Shimizu; Naomichi Baba

doi:10.1271/bbb.60650

Synthesis of lipid derivatives of pyrrole polyamide and their biological activity

Masahiko Yamamoto, Changjin Zhu, Lui Yi, Zheng Rong, Yoshie Miura, Minoru Izumi, Shuhei Nakajima, Ken Ichi Tanamoto, Sakayu Shimizu, Naomichi Baba

Research output: Contribution to journal › Article › peer-review

Abstract

Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.

Original language	English
Pages (from-to)	1078-1082
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	71
Issue number	4
DOIs	https://doi.org/10.1271/bbb.60650
Publication status	Published - 2007

Keywords

Cancer cell
Human immunodeficiency virus (HIV)-II
Lipid
Phospholipid
Pyrrole polyamide

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.60650

Cite this

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abstract = "Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.",

keywords = "Cancer cell, Human immunodeficiency virus (HIV)-II, Lipid, Phospholipid, Pyrrole polyamide",

author = "Masahiko Yamamoto and Changjin Zhu and Lui Yi and Zheng Rong and Yoshie Miura and Minoru Izumi and Shuhei Nakajima and Tanamoto, {Ken Ichi} and Sakayu Shimizu and Naomichi Baba",

year = "2007",

doi = "10.1271/bbb.60650",

language = "English",

volume = "71",

pages = "1078--1082",

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publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

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TY - JOUR

T1 - Synthesis of lipid derivatives of pyrrole polyamide and their biological activity

AU - Yamamoto, Masahiko

AU - Zhu, Changjin

AU - Yi, Lui

AU - Rong, Zheng

AU - Miura, Yoshie

AU - Izumi, Minoru

AU - Nakajima, Shuhei

AU - Tanamoto, Ken Ichi

AU - Shimizu, Sakayu

AU - Baba, Naomichi

PY - 2007

Y1 - 2007

N2 - Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.

AB - Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.

KW - Cancer cell

KW - Human immunodeficiency virus (HIV)-II

KW - Lipid

KW - Phospholipid

KW - Pyrrole polyamide

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UR - http://www.scopus.com/inward/citedby.url?scp=34247520169&partnerID=8YFLogxK

U2 - 10.1271/bbb.60650

DO - 10.1271/bbb.60650

M3 - Article

C2 - 17420577

AN - SCOPUS:34247520169

SN - 0916-8451

VL - 71

SP - 1078

EP - 1082

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 4

ER -

Synthesis of lipid derivatives of pyrrole polyamide and their biological activity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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