Synthesis of sominone and its derivatives based on an RCM strategy: Discovery of a novel anti-alzheimer's disease medicine candidate "denosomin"

Yuji Matsuya; Yu Ichiro Yamakawa; Chihiro Tohda; Kiyoshi Teshigawara; Masashi Yamada; Hideo Nemoto

doi:10.1021/ol901553w

Synthesis of sominone and its derivatives based on an RCM strategy: Discovery of a novel anti-alzheimer's disease medicine candidate "denosomin"

Yuji Matsuya, Yu Ichiro Yamakawa, Chihiro Tohda, Kiyoshi Teshigawara, Masashi Yamada, Hideo Nemoto

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

(Figure Presrnted) Synthesis of sominone was achieved starting from dehydroepiandrosterone on the basis of an RCM strategy for the construction of a δ-lactone side chain. This synthetic protocol was applied for the synthesis of several analogous derivatives including 1-deoxy-24-norsominone (denosomin), which was revealed to exhibit notable bioactivities for new antidementia chemotherapy, exceeding the original natural compound sominone.

Original language	English
Pages (from-to)	3970-3973
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	17
DOIs	https://doi.org/10.1021/ol901553w
Publication status	Published - Sept 3 2009
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol901553w

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AU - Tohda, Chihiro

AU - Teshigawara, Kiyoshi

AU - Yamada, Masashi

AU - Nemoto, Hideo

PY - 2009/9/3

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Synthesis of sominone and its derivatives based on an RCM strategy: Discovery of a novel anti-alzheimer's disease medicine candidate "denosomin"

Abstract

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