Synthetic cobalt bleomycin models as a photochemical DNA cleaver

Isao Saito; Takashi Morii; Tatsuhiko Obayashi; Takashi Sera; Hiroshi Sugiyama; Teruo Matsuura

doi:10.1039/C39890000360

Synthetic cobalt bleomycin models as a photochemical DNA cleaver

Isao Saito, Takashi Morii, Tatsuhiko Obayashi, Takashi Sera, Hiroshi Sugiyama, Teruo Matsuura

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Simplified synthetic models of the bleomycin cobalt complex which contain the AMPHIS {N-[6-(2-aminoethylaminomethyl)pyridin-2-ylcarbonyl]histidine} metal-ion binding ligand and DNA binding component have been prepared; the cobalt complexes cleaved DNA upon photoirradiation.

Original language	English
Pages (from-to)	360-362
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	6
DOIs	https://doi.org/10.1039/C39890000360
Publication status	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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10.1039/C39890000360

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title = "Synthetic cobalt bleomycin models as a photochemical DNA cleaver",

abstract = "Simplified synthetic models of the bleomycin cobalt complex which contain the AMPHIS {N-[6-(2-aminoethylaminomethyl)pyridin-2-ylcarbonyl]histidine} metal-ion binding ligand and DNA binding component have been prepared; the cobalt complexes cleaved DNA upon photoirradiation.",

author = "Isao Saito and Takashi Morii and Tatsuhiko Obayashi and Takashi Sera and Hiroshi Sugiyama and Teruo Matsuura",

year = "1989",

doi = "10.1039/C39890000360",

language = "English",

pages = "360--362",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

publisher = "Royal Society of Chemistry",

number = "6",

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TY - JOUR

T1 - Synthetic cobalt bleomycin models as a photochemical DNA cleaver

AU - Saito, Isao

AU - Morii, Takashi

AU - Obayashi, Tatsuhiko

AU - Sera, Takashi

AU - Sugiyama, Hiroshi

AU - Matsuura, Teruo

PY - 1989

Y1 - 1989

N2 - Simplified synthetic models of the bleomycin cobalt complex which contain the AMPHIS {N-[6-(2-aminoethylaminomethyl)pyridin-2-ylcarbonyl]histidine} metal-ion binding ligand and DNA binding component have been prepared; the cobalt complexes cleaved DNA upon photoirradiation.

AB - Simplified synthetic models of the bleomycin cobalt complex which contain the AMPHIS {N-[6-(2-aminoethylaminomethyl)pyridin-2-ylcarbonyl]histidine} metal-ion binding ligand and DNA binding component have been prepared; the cobalt complexes cleaved DNA upon photoirradiation.

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U2 - 10.1039/C39890000360

DO - 10.1039/C39890000360

M3 - Article

AN - SCOPUS:0024581061

SN - 0022-4936

SP - 360

EP - 362

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 6

ER -

Synthetic cobalt bleomycin models as a photochemical DNA cleaver

Abstract

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