Synthetic study on 13-oxyingenol: construction of the full carbon framework

Ichiro Hayakawa; Yuki Asuma; Takayuki Ohyoshi; Kenta Aoki; Hideo Kigoshi

doi:10.1016/j.tetlet.2007.06.135

Synthetic study on 13-oxyingenol: construction of the full carbon framework

Ichiro Hayakawa, Yuki Asuma, Takayuki Ohyoshi, Kenta Aoki, Hideo Kigoshi

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

13-Oxyingenol is a diterpenoid isolated from Euphorbia kansui, and its derivatives have strong anti-HIV activity. We achieved the construction of inside-outside framework of 13-oxyingenol by using ring-closing olefin metathesis.

Original language	English
Pages (from-to)	6221-6224
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	35
DOIs	https://doi.org/10.1016/j.tetlet.2007.06.135
Publication status	Published - Aug 27 2007
Externally published	Yes

Keywords

13-Oxyingenol
Anti-HIV activity
Ring-closing olefin metathesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2007.06.135

Cite this

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title = "Synthetic study on 13-oxyingenol: construction of the full carbon framework",

abstract = "13-Oxyingenol is a diterpenoid isolated from Euphorbia kansui, and its derivatives have strong anti-HIV activity. We achieved the construction of inside-outside framework of 13-oxyingenol by using ring-closing olefin metathesis.",

keywords = "13-Oxyingenol, Anti-HIV activity, Ring-closing olefin metathesis",

author = "Ichiro Hayakawa and Yuki Asuma and Takayuki Ohyoshi and Kenta Aoki and Hideo Kigoshi",

note = "Funding Information: This work was supported in part by the 21st COE program and Grant-in-Aid for Scientific Research on Priority Areas (No. 16073204, {\textquoteleft}Creation of Biologically Functional Molecules{\textquoteright}) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan and University of Tsukuba Projects.",

year = "2007",

month = aug,

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doi = "10.1016/j.tetlet.2007.06.135",

language = "English",

volume = "48",

pages = "6221--6224",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Synthetic study on 13-oxyingenol

T2 - construction of the full carbon framework

AU - Hayakawa, Ichiro

AU - Asuma, Yuki

AU - Ohyoshi, Takayuki

AU - Aoki, Kenta

AU - Kigoshi, Hideo

N1 - Funding Information: This work was supported in part by the 21st COE program and Grant-in-Aid for Scientific Research on Priority Areas (No. 16073204, ‘Creation of Biologically Functional Molecules’) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan and University of Tsukuba Projects.

PY - 2007/8/27

Y1 - 2007/8/27

N2 - 13-Oxyingenol is a diterpenoid isolated from Euphorbia kansui, and its derivatives have strong anti-HIV activity. We achieved the construction of inside-outside framework of 13-oxyingenol by using ring-closing olefin metathesis.

AB - 13-Oxyingenol is a diterpenoid isolated from Euphorbia kansui, and its derivatives have strong anti-HIV activity. We achieved the construction of inside-outside framework of 13-oxyingenol by using ring-closing olefin metathesis.

KW - 13-Oxyingenol

KW - Anti-HIV activity

KW - Ring-closing olefin metathesis

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DO - 10.1016/j.tetlet.2007.06.135

M3 - Article

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SN - 0040-4039

VL - 48

SP - 6221

EP - 6224

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 35

ER -

Synthetic study on 13-oxyingenol: construction of the full carbon framework

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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